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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

Renewal of Intestinal Stem Cells

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

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Related Experiment Video

Updated: Jun 16, 2026

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres

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Published on: July 22, 2020

New Therapeutics Targeting Colon Cancer Stem Cells.

Arun Thenappan, Ying Li, Kirti Shetty

Current Colorectal Cancer Reports

|February 12, 2010

Summary

Colorectal cancer (CRC) stem cells drive tumor growth and offer new therapeutic targets. Understanding their self-renewal and Wnt/TGF-β pathway control is key to developing effective CRC treatments.

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Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

Area of Science:

Oncology
Gastroenterology
Stem Cell Biology

Background:

Tumor-initiating colorectal cancer (CRC) stem cells are crucial in CRC pathogenesis.
Potential CRC stem cell markers include CD133, CD44, and Lgr5.
Wnt and transforming growth factor (TGF)-β pathways regulate stem cell self-renewal, proliferation, and differentiation.

Purpose of the Study:

To review the current understanding of colorectal cancer stem cells.
To explore the role of Wnt and TGF-β signaling in CRC stem cell regulation.
To propose rational therapeutic strategies targeting CRC stem cells.

Main Methods:

Literature review of studies on colorectal cancer stem cells.
Analysis of the roles of Wnt and TGF-β signaling pathways.
Identification of potential therapeutic targets within CRC stem cell biology.

Main Results:

Disruption of Wnt signaling (e.g., APC loss) is an early event in CRC.
TGF-β signaling acts as a tumor suppressor; mutations are linked to aggressive CRC.
Loss of β(2)-spectrin correlates with disrupted colonic cell polarity and architecture.

Conclusions:

Targeting colorectal cancer stem cells presents a promising therapeutic avenue.
Understanding stem cell pathways is essential for novel CRC treatment development.
This review suggests rational approaches for targeting CRC stem cells in advanced disease.