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Protection by D609 through cell-cycle regulation after stroke

Rao Muralikrishna Adibhatla1, James F Hatcher

  • 1Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792-3232, USA. adibhatl@neurosurg.wisc.edu

Molecular Neurobiology
|February 12, 2010
PubMed
Summary

D609 treatment after stroke significantly reduced brain infarction by inhibiting sphingomyelin synthase, increasing ceramide levels, and inducing cell-cycle arrest. This neuroprotective effect involves up-regulating p21 and hypophosphorylating Rb.

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