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beta-Cyclodextrin hydrogels containing naphthaleneacetic acid for pH-sensitive release.

Xia Yang1, Jin-Chul Kim

  • 1School of Biotechnology & Bioengineering, Institute of Bioscience and Biotechnology, Kangwon National University, 192-1, Hyoja 2 dong, Chunchon, Kangwon-do 200-701, Korea.

Biotechnology and Bioengineering
|February 12, 2010
PubMed
Summary

This study developed pH-sensitive beta-cyclodextrin (beta-CD) hydrogels. Lower cross-linker ratios enhanced drug release and pH sensitivity due to increased swelling.

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Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Biomedical Engineering

Background:

  • Beta-cyclodextrin (beta-CD) hydrogels are investigated for controlled release applications.
  • pH sensitivity is a desirable characteristic for targeted drug delivery systems.

Purpose of the Study:

  • To synthesize and characterize pH-sensitive beta-cyclodextrin hydrogels.
  • To investigate the effect of cross-linker concentration on hydrogel properties and release kinetics.
  • To evaluate the loading and release of naphthaleneacetic acid (NAA) within the hydrogel matrix.

Main Methods:

  • Beta-cyclodextrin (beta-CD) hydrogels were prepared using epichlorohydrin (EPI) as a cross-linker at varying molar ratios (EPI:beta-CD = 8:1, 10:1, 15:1).
  • Naphthaleneacetic acid (NAA) was loaded into the hydrogels via hydrophobic interactions.
  • The release of blue dextran was monitored at different pH values to assess drug release profiles.
  • Swelling ratios of the hydrogels were measured to correlate with release behavior.

Main Results:

  • Hydrogel swelling ratio increased with decreasing EPI to beta-CD molar ratio.
  • A lower EPI to beta-CD ratio resulted in a higher degree of blue dextran release.
  • The hydrogels exhibited pH-dependent release, with increased release at higher pH.
  • The observed release and pH sensitivity were attributed to the higher swelling ratio of hydrogels with lower cross-linker content.

Conclusions:

  • The cross-linker to beta-CD ratio significantly influences hydrogel swelling, drug release, and pH sensitivity.
  • These beta-CD hydrogels demonstrate potential for pH-responsive drug delivery applications.
  • Optimizing cross-linker concentration is crucial for tailoring hydrogel performance for specific delivery needs.