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Published on: June 12, 2021
ICD therapy in children and young adults: low incidence of inappropriate shock delivery
Micha P Botsch1, Birgit Franzbach, Bernd Opgen-Rhein
1Department of Pediatric Cardiology and Congenital Heart Disease, Charité Universitaetsmedizin, Berlin, Germany. micha.botsch@charite.de
Insights
Implantable cardioverter defibrillator (ICD) therapy is feasible in pediatric patients. Combining antiarrhythmic drugs, ablation, and tailored programming significantly reduces inappropriate shocks in young patients receiving ICDs.
Area of Science:
- Pediatric Cardiology
- Electrophysiology
- Medical Device Technology
Background:
- Implantable cardioverter defibrillator (ICD) therapy is a viable treatment for life-threatening arrhythmias in pediatric patients.
- However, high rates of inappropriate shock delivery have been reported in recent studies.
Purpose of the Study:
- To evaluate the incidence of inappropriate shock delivery in pediatric patients receiving ICDs.
- To identify strategies that minimize inappropriate shocks in this population.
Main Methods:
- Retrospective analysis of 33 pediatric patients who received ICDs between 2001 and 2007.
- Data collected included cardiac disorders, arrhythmias, medications, ablation procedures, device programming, and ICD therapies.
- Patients received tailored treatment including antiarrhythmic drugs and ablation procedures.
Main Results:
- A total of 33 pediatric patients underwent ICD implantation.
- Most patients received antiarrhythmic drugs (85%), and 27% underwent ablation procedures.
- Only two inappropriate shocks (delivered for atrial flutter) occurred among 63 total therapies in 11 patients, with 22 patients receiving no therapies.
Conclusions:
- A multimodal approach combining antiarrhythmic drug therapy, ablation procedures, and individualized ICD programming effectively reduces inappropriate shock delivery in children and young adults.
- Improved device and lead technology further contributes to minimizing adverse events.
Introduction:
Implantable cardioverter defibrillator (ICD) therapy of life-threatening arrhythmias in pediatric patients is feasible; however, recent studies report a high incidence of inappropriate shock deliveries.
Methods:
The data of all recipients of an ICD at the Charité, Department of Pediatric Cardiology, between January 2001 and November 2007 were retrospectively analyzed regarding underlying cardiac disorders, arrhythmias, medication, ablation procedures, leads and devices, programming, and ICD therapies.
Results:
A total of 33 patients underwent ICD implantation, with a median age of 16.5 years (range 8-36 years) and a mean weight of 61 +/- 20.9 kg. Underlying cardiac disorders were electrical heart disease (27%), cardiomyopathy (30%), congenital heart disease (33%), and others (9%). Eighty-five percent received antiarrhythmic drugs, and 12 ablation procedures were performed in nine patients (27%). The devices were programmed individually according to the underlying diseases and arrhythmias. During follow-up, a total of 63 shock therapies were delivered in 11 patients, while a majority of 34 shocks occurred in one patient (no therapies in 22 of 33 patients). Only two such therapies were inappropriate, both delivered for atrial flutter.
Conclusions:
In children and young adults receiving ICD therapy, the combination of strategies to prevent ventricular arrhythmias using specific drug therapy, ablation procedures, and individual programming with improved devices and leads causes a low incidence of inappropriate shock delivery.
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