ICD therapy in children and young adults: low incidence of inappropriate shock delivery

Micha P Botsch1, Birgit Franzbach, Bernd Opgen-Rhein

  • 1Department of Pediatric Cardiology and Congenital Heart Disease, Charité Universitaetsmedizin, Berlin, Germany. micha.botsch@charite.de

Insights

Implantable cardioverter defibrillator (ICD) therapy is feasible in pediatric patients. Combining antiarrhythmic drugs, ablation, and tailored programming significantly reduces inappropriate shocks in young patients receiving ICDs.

Area of Science:

  • Pediatric Cardiology
  • Electrophysiology
  • Medical Device Technology

Background:

  • Implantable cardioverter defibrillator (ICD) therapy is a viable treatment for life-threatening arrhythmias in pediatric patients.
  • However, high rates of inappropriate shock delivery have been reported in recent studies.

Purpose of the Study:

  • To evaluate the incidence of inappropriate shock delivery in pediatric patients receiving ICDs.
  • To identify strategies that minimize inappropriate shocks in this population.

Main Methods:

  • Retrospective analysis of 33 pediatric patients who received ICDs between 2001 and 2007.
  • Data collected included cardiac disorders, arrhythmias, medications, ablation procedures, device programming, and ICD therapies.
  • Patients received tailored treatment including antiarrhythmic drugs and ablation procedures.

Main Results:

  • A total of 33 pediatric patients underwent ICD implantation.
  • Most patients received antiarrhythmic drugs (85%), and 27% underwent ablation procedures.
  • Only two inappropriate shocks (delivered for atrial flutter) occurred among 63 total therapies in 11 patients, with 22 patients receiving no therapies.

Conclusions:

  • A multimodal approach combining antiarrhythmic drug therapy, ablation procedures, and individualized ICD programming effectively reduces inappropriate shock delivery in children and young adults.
  • Improved device and lead technology further contributes to minimizing adverse events.
Abstract

Related Concept Videos

Blood Pressure Imbalances and Circulatory Shock01:24

Blood Pressure Imbalances and Circulatory Shock

Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
Cardiopulmonary Resuscitation III: AED Use01:23

Cardiopulmonary Resuscitation III: AED Use

Introduction to AEDAn Automated External Defibrillator (AED) is a portable medical device that analyzes the heart's rhythm and, if necessary, delivers an electrical shock to help the heart re-establish an effective rhythm during sudden cardiac arrest (SCA). SCA occurs when the heart suddenly and unexpectedly stops beating, leading to a loss of blood flow to the brain and other vital organs. In such emergencies, time is of the essence, and using an AED, combined with Cardiopulmonary...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...