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A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle
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Published on: January 11, 2018

Profiling type I collagen gene expression in growing mandibular structures.

P Römer1, J Weingärtner, P Proff

  • 1Department of Orthodontics, University Medical Center Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany. piero.roemer@gmx.de

Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft
|February 13, 2010
PubMed
Summary
This summary is machine-generated.

Type I collagen gene expression in rat mandible development peaks at postnatal day 10 in the ramus and day 21 in the alveolar process, indicating key growth periods.

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Area of Science:

  • Developmental Biology
  • Genetics
  • Oral and Maxillofacial Surgery

Background:

  • Craniofacial development is a complex process involving coordinated bone growth.
  • Type I collagen is a major structural protein in bone, crucial for its development and integrity.

Purpose of the Study:

  • To investigate the temporal gene expression patterns of type I collagen during postnatal rat mandibular development.
  • To identify key developmental stages for mandibular growth based on collagen expression.

Main Methods:

  • Temporal gene expression analysis of type I collagen.
  • Cross-sectional study design across critical postnatal time points in rats.
  • Analysis focused on the coronoid process, alveolar process, and mandibular angle.

Main Results:

  • Prominent type I collagen gene expression was observed at postnatal day 10 in the mandibular ramus.
  • Significant type I collagen expression was detected at postnatal day 21 in the alveolar process.
  • Findings align with previous proliferation studies in facial bone development.

Conclusions:

  • Mandibular development in rats shows distinct phases of rapid growth between postnatal days 10 and 21.
  • Type I collagen expression serves as a reliable indicator for these critical growth periods in the rat mandible.