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Related Concept Videos

Pharmacovigilance01:19

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
Drug Regulation01:25

Drug Regulation

Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
Dosage Regimens: Partial Pharmacokinetic Parameters01:01

Dosage Regimens: Partial Pharmacokinetic Parameters

It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

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Related Experiment Video

Updated: Jun 16, 2026

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
07:02

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

Published on: February 11, 2019

Functionality test for drug safety alerting in computerized physician order entry systems.

Heleen van der Sijs1, Rachida Bouamar, Teun van Gelder

  • 1Department of Hospital Pharmacy, Erasmus University Medical Centre, Rotterdam, The Netherlands. i.vandersijs@erasmusmc.nl

International Journal of Medical Informatics
|February 13, 2010
PubMed
Summary
This summary is machine-generated.

A new test revealed significant variability in drug safety alerting within hospital computerized physician order entry (CPOE) systems. Some essential clinical decision support features were missing, prompting pharmacists to develop workarounds.

Related Experiment Videos

Last Updated: Jun 16, 2026

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
07:02

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

Published on: February 11, 2019

Area of Science:

  • Health Informatics
  • Clinical Pharmacy
  • Medical Software Evaluation

Background:

  • Computerized physician order entry (CPOE) systems are crucial for medication safety in hospitals.
  • Effective drug safety alerting within CPOE is essential to prevent adverse drug events.
  • Evaluating the real-world functionality of these alerts is vital for improving patient care.

Purpose of the Study:

  • To assess the drug safety alerting capabilities of hospital CPOE systems using a novel, comprehensive testing method.
  • To identify variations in alert functionality across different CPOE systems used in Dutch hospitals.

Main Methods:

  • A comparative evaluation of 6 Dutch hospital CPOE systems was conducted.
  • A test suite with 29 items for sensitivity and 19 for specificity was developed and applied.
  • Qualitative interviews with 16 hospital pharmacists explored missing functionalities and pharmacy-led solutions.

Main Results:

  • Sensitivity scores ranged from 0.38 to 0.79, and specificity from 0.11 to 0.84, indicating significant performance differences.
  • All systems included "within-order" and "patient-specific" checks, but alerts for laboratory data and new conditions were largely absent.
  • Pharmacists identified critical missing alerts for contraindications and dose regimens, developing supplementary checks and rules.

Conclusions:

  • The developed test effectively differentiated CPOE system functionality, highlighting substantial variations.
  • Basic clinical decision support functionalities were lacking in some CPOE systems.
  • Hospital pharmacists actively compensated for system deficiencies by implementing additional manual checks and developing custom clinical rules.