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Inflammation01:38

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Related Experiment Video

Updated: Jun 16, 2026

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
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Exploring a regulatory role for mast cells: 'MCregs'?

Barbara Frossi1, Giorgia Gri, Claudio Tripodo

  • 1Department of Biomedical Science and Technology, University of Udine, P. le M. Kolbe 4, 33100 Udine, Italy.

Trends in Immunology
|February 13, 2010
PubMed
Summary

Mast cells, not just T cells, regulate immune responses. These versatile cells manage immune cell activity and direct responses against pathogens and abnormal cells, with complex roles throughout immune processes.

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Last Updated: Jun 16, 2026

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Immune responses are regulated by specialized cells, traditionally T cells.
  • Mast cells are increasingly recognized for their regulatory roles in immunity.

Purpose of the Study:

  • To explore the multifaceted and often contradictory functions of mast cells in immune regulation.
  • To clarify the role of mast cells at the intersection of innate and adaptive immunity.

Main Methods:

  • Review of existing literature on mast cell functions in immune responses.
  • Analysis of studies investigating mast cell interactions with effector cells and pathogens.

Main Results:

  • Mast cells exhibit diverse regulatory functions, including suppression and redirection of effector cells.
  • These functions vary depending on the stage of the immune response.
  • Mast cells operate at the critical interface between innate and adaptive immunity.

Conclusions:

  • Mast cells possess complex and dynamic regulatory capabilities within the immune system.
  • Further research is needed to fully elucidate the distinct roles of mast cells in various immune contexts.