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Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43
Published on: September 11, 2020
Serotype-specific pneumococcal disease may be influenced by mannose-binding lectin deficiency
1Centro de Investigação em Saúde de Manhiça, Ministerio de Saúde, Maputo, Mozambique. xavier_valles04@hotmail.com
The European Respiratory Journal
|February 13, 2010
Summary
Mannose-binding lectin pathway deficiencies are linked to invasive pneumococcal disease, particularly with less invasive Streptococcus pneumoniae serotypes. Serotype invasiveness influences susceptibility in MBL-deficient individuals.
Area of Science:
- Immunology
- Genetics
- Infectious Diseases
Background:
- Invasive pneumococcal disease (IPD) susceptibility is complex.
- The role of mannose-binding lectin (MBL) pathway deficiencies in IPD remains unclear.
- Streptococcus pneumoniae invasiveness varies by serotype.
Purpose of the Study:
- To investigate the association between MBL2 and MASP2 genetic variants and IPD.
- To explore the influence of Streptococcus pneumoniae serotype distribution on this association.
Main Methods:
- Hospital-based case-control study in Mozambican children (2002-2003).
- Invasive pneumococcal disease cases identified via blood culture and serotyping.
- Sequence-based typing of MBL2 and MASP2 polymorphic regions.
Main Results:
- High frequency (43%) of MBL2 genotypes associated with low MBL serum levels.
- MBL-deficient genotypes linked to IPD caused by low-invasive serotypes (OR 5.55, p=0.01).
Conclusions:
- Serotype invasiveness may modulate pneumococcal disease susceptibility in MBL-deficient individuals.
- Future genetic association studies should consider S. pneumoniae type-specific capsular serotypes.
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