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Serotype-specific pneumococcal disease may be influenced by mannose-binding lectin deficiency

X Vallès1, A Roca, F Lozano

  • 1Centro de Investigação em Saúde de Manhiça, Ministerio de Saúde, Maputo, Mozambique. xavier_valles04@hotmail.com

The European Respiratory Journal
|February 13, 2010
PubMed

Insights

Mannose-binding lectin pathway deficiencies are linked to invasive pneumococcal disease, particularly with less invasive Streptococcus pneumoniae serotypes. Serotype invasiveness influences susceptibility in MBL-deficient individuals.

Area of Science:

  • Immunology
  • Genetics
  • Infectious Diseases

Background:

  • Invasive pneumococcal disease (IPD) susceptibility is complex.
  • The role of mannose-binding lectin (MBL) pathway deficiencies in IPD remains unclear.
  • Streptococcus pneumoniae invasiveness varies by serotype.

Purpose of the Study:

  • To investigate the association between MBL2 and MASP2 genetic variants and IPD.
  • To explore the influence of Streptococcus pneumoniae serotype distribution on this association.

Main Methods:

  • Hospital-based case-control study in Mozambican children (2002-2003).
  • Invasive pneumococcal disease cases identified via blood culture and serotyping.
  • Sequence-based typing of MBL2 and MASP2 polymorphic regions.

Main Results:

  • High frequency (43%) of MBL2 genotypes associated with low MBL serum levels.
  • MBL-deficient genotypes linked to IPD caused by low-invasive serotypes (OR 5.55, p=0.01).

Conclusions:

  • Serotype invasiveness may modulate pneumococcal disease susceptibility in MBL-deficient individuals.
  • Future genetic association studies should consider S. pneumoniae type-specific capsular serotypes.

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