Cellular changes in primary rabbit kidney cells resembling those caused by certain viruses

Changes suggestive of being caused by a virus have recently been observed in primary rabbit kidney cells. In their nature and development they resembled those of parvoviruses. The changes were found in cultures from rabbits from various sources within and outside The Netherlands. If the changes are caused by a viral agent, this agent is most probably of rabbit origin, as exogenous infection, for example through trypsin, could almost certainly be excluded. However, no virus has yet been isolated nor could particles be made visible by electron microscopy in affected cells. Hemagglutination could not be demonstrated nor could antibody in rabbits. The possible nature of these changes will be discussed.