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Lipid-alginate interactions render changes in phospholipid bilayer permeability.

S Cohen1, M C Bañó, M Chow

  • 1Department of Chemical Engineering, M.I.T., Cambridge, MA 02139.

Biochimica Et Biophysica Acta
|March 18, 1991
PubMed
Summary
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Encapsulating lipid vesicles in Ca-alginate and poly(L-lysine) causes unusual

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Physical Chemistry

Background:

  • Lipid vesicles, such as liposomes, typically exhibit continuous release of encapsulated contents.
  • Controlled release systems are crucial for targeted and efficient delivery of therapeutic agents.

Purpose of the Study:

  • To investigate the mechanism behind the 'burst' release of contents from lipid vesicles entrapped in Ca-alginate and coated with poly(L-lysine).
  • To elucidate the molecular interactions between lipids and alginate that alter vesicle barrier properties.

Main Methods:

  • Differential scanning calorimetry (DSC) to analyze thermal properties of liposomes.
  • Size-exclusion chromatography (SEC) to assess changes in liposome structure and elution behavior.
  • Molecular-level investigations of lipid-alginate interactions.

Related Experiment Videos

Main Results:

  • Alginate insertion into the lipid bilayer of vesicles was observed.
  • A significant reduction (4-fold) in phase transition enthalpy of liposomes upon alginate exposure, without altering melting temperature.
  • SEC indicated changes in liposome size or structure due to alginate interaction.

Conclusions:

  • Lipid-alginate interactions fundamentally alter the barrier properties of lipid vesicles.
  • The insertion of alginate into the lipid bilayer is responsible for the observed 'burst' release phenomenon.
  • The nature of these interactions is influenced by phospholipid head group charge and phase transition temperature.