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Related Experiment Video

Updated: Jul 23, 2025

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

Published on: October 24, 2018

Prefrontal Cortex Astroglia Modulate Anhedonia-like Behavior.

S A Codeluppi^1,2, M Xu³, Y Bansal^1,2

¹Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, Canada.

Research Square

|July 18, 2023

Summary

This summary is machine-generated.

Reduced glial fibrillary acidic protein (GFAP)+ cells in the prefrontal cortex (PFC) are linked to depression. This study shows PFC GFAP+ cell depletion causes anhedonia, while enhancing their activity reverses stress-induced anhedonia.

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Last Updated: Jul 23, 2025

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

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Published on: October 24, 2018

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Published on: February 4, 2015

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes

Published on: February 5, 2018

Area of Science:

Neuroscience
Cell Biology

Background:

Reductions in glial fibrillary acidic protein (GFAP)+ astroglia within the prefrontal cortex (PFC) are a consistent finding in patients with depression.
Similar reductions are observed in rodent models subjected to chronic stress, suggesting a role for these cells in depressive disorders.

Conclusions:

Cortical astroglia expressing GFAP play a critical role in the development and manifestation of anhedonia.
Targeting astroglia represents a promising therapeutic strategy for treating depression, particularly symptoms related to anhedonia.