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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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Apo(a) phenotyping and long-term prognosis for coronary artery disease

M A Baños-González1, M A Peña-Duque, E Anglés-Cano

  • 1Instituto Nacional de Cardiología "Ignacio Chávez", Departamentos de Biología Molecular, Mexico, D.F.

Clinical Biochemistry
|February 16, 2010
PubMed

Insights

Small apo(a) isoforms predict major adverse cardiovascular and cerebrovascular events in coronary artery disease patients. Lp(a) concentration and fibrin-binding showed associations but were not statistically significant.

Area of Science:

  • Cardiovascular Medicine
  • Lipidology
  • Genetics

Background:

  • Lipoprotein(a) [Lp(a)] is a lipoprotein that plays a role in atherosclerosis.
  • The size of apolipoprotein(a) [apo(a)] isoforms and Lp(a) affinity for fibrin are potential risk factors for cardiovascular events.
  • Understanding these factors can help predict outcomes in patients with coronary artery disease.

Purpose of the Study:

  • To determine if Lp(a) concentration, apo(a) size, or Lp(a) fibrin-binding predict major adverse cardiovascular and cerebrovascular events (MACCE).
  • To assess the association of these factors with cardiac death, myocardial infarction, unstable angina, revascularization, and stroke.

Main Methods:

  • A case-controlled study analyzed 68 coronary artery disease patients.
  • Evaluated Lp(a) concentration, apo(a) size, and Lp(a) fibrin-binding.
  • Kaplan-Meier survival analysis was used over a median 8-year follow-up.

Main Results:

  • Small-sized apo(a) isoforms were identified as predictors of MACCE.
  • Lp(a) concentration and apo(a) fibrin-binding showed an association with MACCE.
  • The association between Lp(a) concentration/fibrin-binding and MACCE was not statistically significant.

Conclusions:

  • Small apo(a) isoforms are an independent risk factor for MACCE in coronary artery disease patients.
  • Lp(a) plasma concentration and apo(a) fibrin-binding were associated with MACCE but did not reach statistical significance.
Abstract

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