Modulation of CD86 expression in skin dendritic cells does not always correlate with changes in DC motility,
Nicolas Bechetoille1, Aurélie Boher, Amandine Gaydon
1BASF Beauty Care Solutions, 32 rue Saint Jean de Dieu, 69007 Lyon, France. nicolas.bechetoille@basf.com
European Journal of Dermatology : EJD
|February 16, 2010
Abstract:
CD86 expression is a well-known activation marker of dendritic cells (DC). In this study, we compared the level of CD86 expression in monocyte-derived skin DC with their motility, migratory abilities and allostimulatory capabilities. We show that motility and migration could be uncoupled from activation and that the immune response-modulating effects of certain compounds may correlate with down-regulation of CD86 expression rather than with effects on motility and migration.


