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Updated: Jun 16, 2026

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

Published on: May 19, 2020

Subacute longitudinal myelitis associated with Behcet's disease.

Jiro Fukae¹, Kazuyuki Noda, Kenji Fujishima

¹Department of Neurology, Juntendo University Shizuoka Hospital, Shizuoka.

Internal Medicine (Tokyo, Japan)

|February 16, 2010

Summary

Neuro-Behcet's disease (NBD) can cause rare myelitis. This case highlights extensive longitudinal myelitis, responding well to steroids, suggesting NBD as a key differential diagnosis.

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Area of Science:

Neurology
Immunology

Background:

Neuro-Behcet's disease (NBD) is a rare neurological complication of Behcet's disease.
Myelitis, or inflammation of the spinal cord, is an uncommon manifestation of NBD.

Observation:

A case of NBD presenting with severe gait instability and spasticity is described.
Spinal MRI revealed extensive, confluent T2 hyperintensities throughout the entire spinal cord with contrast enhancement.

Findings:

The patient experienced marked improvement following high-dose steroid therapy.
Follow-up MRI confirmed significant resolution of the myelitis.

Implications:

This report details the first description of longitudinal myelitis affecting the entire spinal cord in NBD.
NBD should be considered in the differential diagnosis of extensive longitudinal myelitis.