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The Motivation for Alcohol Reward: Predictors of Progressive-Ratio Intravenous Alcohol Self-Administration in Humans
Published on: April 28, 2022
Is self-reported "moderate" drinking in the cardiovascular benefit range associated with alcoholic behavior? A
Khawaja Afzal Ammar1, Saquib Samee, Robert Colligan
1Mayo Clinic and Foundation, Rochester, MN 55905, USA. ammar.khawaja@mayo.edu
Even moderate alcohol consumption may be linked to problematic drinking behaviors. This study found that many individuals with alcohol use disorders reported drinking within recommended limits, complicating recommendations for cardiovascular health.
Area of Science:
- Public Health
- Cardiology
- Addiction Medicine
Background:
- Physicians face challenges in recommending alcohol for cardiovascular risk prevention due to potential for alcohol-related problems.
- Understanding the relationship between alcohol consumption levels and alcohol-related behaviors is crucial for clinical guidance.
Purpose of the Study:
- To identify a threshold for daily alcohol intake beyond which the risk of developing alcoholic behavior significantly increases.
- To inform physicians about safe alcohol consumption limits for cardiovascular risk prevention.
Main Methods:
- A population-based sample of 2,042 adults aged 45+ was randomly selected.
- Alcohol drinking behavior was assessed using the Self-Administered Alcoholism Screening Test.
- Alcohol quantity was quantified via questionnaire, and cardiovascular disease prevalence was reviewed from medical records.
Main Results:
- Optimal alcohol use (<= 2 drinks/day) was associated with reduced odds of cardiovascular disease.
- However, a significant proportion of individuals with alcoholism (43%) and problem drinking (82%) reported consumption within this 'optimal' range.
- Underreporting of alcohol use by individuals with alcoholism was noted.
Conclusions:
- The overlap between 'optimal' alcohol use ranges and problematic drinking behaviors explains physician reluctance to recommend alcohol for cardiovascular benefits.
- Current guidelines for alcohol consumption may not adequately capture risks for individuals prone to alcohol-related problems.
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