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Patented bioavailability enhancement techniques of silymarin
Shamama Javed1, Kanchan Kohli, Mushir Ali
1Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062, India. shamamajaved@gmail.com
Recent Patents on Drug Delivery & Formulation
|February 17, 2010
Summary
This review critically examines patents on novel techniques to enhance silymarin bioavailability. Improving oral absorption of this potent herbal compound is key to its therapeutic potential.
Area of Science:
- Pharmacology
- Natural Products Chemistry
Background:
- Silymarin, a polyphenolic fraction from Silybum marianum, possesses known therapeutic uses for liver ailments and poisoning.
- Its clinical application is significantly hindered by poor oral absorption and low bioavailability.
- Growing consumer preference for natural medicines fuels the demand for effective phytopharmaceutical formulations.
Purpose of the Study:
- To critically review patents on emerging trends and techniques for enhancing silymarin bioavailability.
- To identify innovative strategies addressing the poor oral absorption of silymarin.
Main Methods:
- Comprehensive review of patent literature focusing on silymarin bioavailability enhancement.
- Analysis of various formulation and delivery techniques described in patents.
Main Results:
- Patents reveal diverse approaches including complexation, derivatization, and solubilization.
- Advanced methods like targeted delivery and controlled delivery systems are explored.
- Miscellaneous techniques also contribute to overcoming silymarin's absorption limitations.
Conclusions:
- Significant patent activity highlights ongoing innovation in improving silymarin bioavailability.
- These patented techniques offer promising avenues to unlock the full therapeutic potential of silymarin.
- Addressing poor oral absorption is crucial for the wider adoption of this natural medicine.
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