Highly luminescent quantum dots functionalized and their conjugation with IgG
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Updated: Jun 16, 2026

Compact Quantum Dots for Single-molecule Imaging
Published on: October 9, 2012
Ping Yang1, Aiyu Zhang, Hongsheng Sun
1School of Materials Science and Engineering, University of Jinan, 250022 Jinan, PR China. mse_yangp@ujn.edu.cn
Abstract:
A sol-gel approach including partially removing capping agents, depositing SiO(2) monomers, and growing a SiO(2) shell was developed to generate a bio-compatible functionalization on CdTe quantum dots (QDs). The QDs retained their high photoluminescence (PL) efficiency after coating with a SiO(2) shell (22.5%) by controlling the surface state of the QDs to decrease PL degradation during a sol-gel preparation. Furthermore, the CdTe QDs with a SiO(2) shell were conjugated with IgG using 3-sulfo-N-hydroxysuccinimide or streptavidin-maleimide as linkers. The biotin-streptavidin linker resulted in a high PL efficiency retained (only ~23% lower than the initial value of the QDs), which is crucial for bio-applications.
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