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Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...

Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
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Primary Symptoms of COPD:

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Related Experiment Video

Updated: Jun 16, 2026

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

ADAM33 gene polymorphisms in chronic obstructive pulmonary disease.

S Pabst¹, C Pizarro Touron, A Gillissen

¹Medizinische Klinik und Poliklinik II, Pulmonary Division, Department of Medicine, Universitätsklinikum Bonn, Bonn, Germany. Stefan.pabst@ukb.uni-bonn.de

European Journal of Medical Research

|February 17, 2010

Summary

Genetic variants in ADAM33 (a disintegrin and metalloprotease 33) are not associated with chronic obstructive pulmonary disease (COPD) development or disease severity. This study found no significant differences in specific ADAM33 single nucleotide polymorphisms (SNPs) between COPD patients and healthy controls.

Related Experiment Videos

Last Updated: Jun 16, 2026

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

Area of Science:

Genetics
Pulmonology
Molecular Biology

Background:

Chronic obstructive pulmonary disease (COPD) pathogenesis involves genetic and environmental factors.
Research into genomic variants influencing COPD susceptibility is ongoing due to the disease's global increase.
The gene a disintegrin and metalloprotease 33 (ADAM33) is a potential candidate for influencing COPD.

Purpose of the Study:

To investigate the association between single nucleotide polymorphisms (SNPs) in the ADAM33 gene and the development of COPD.
To determine if specific ADAM33 polymorphisms affect the clinical course and stability of COPD.

Main Methods:

Genotyping of 150 German COPD patients and 152 healthy controls for F+1 and S_2 SNPs in ADAM33.
Analysis of allele frequencies for G to A and C to G base pair exchanges.
Subgroup analysis of COPD patients (60 stable, 90 unstable) to assess impact on disease course.

Main Results:

No significant difference in the frequency of the ADAM33 F+1 A allele was observed between COPD patients (stable and unstable) and healthy controls.
The frequency of the ADAM33 S_2 mutant allele also showed no significant difference between stable COPD patients, unstable COPD patients, and controls.
Statistical analysis (P values) indicated no significant association for either tested SNP with COPD presence or disease stability.

Conclusions:

The tested single nucleotide polymorphisms (SNPs) in the ADAM33 gene are not significantly associated with the development of COPD in the German population.
These specific ADAM33 polymorphisms do not appear to influence the stability or clinical course of chronic obstructive pulmonary disease.