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Related Concept Videos

Gene Families01:57

Gene Families

Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Gene Families01:57

Gene Families

Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

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Related Experiment Video

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A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

QuickGO: a user tutorial for the web-based Gene Ontology browser.

Rachael P Huntley1, David Binns, Emily Dimmer

  • 1European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.

Database : the Journal of Biological Databases and Curation
|February 17, 2010
PubMed
Summary
This summary is machine-generated.

QuickGO is a web tool for exploring Gene Ontology (GO) annotations, aiding researchers in understanding gene product functions. Its recent redevelopment offers enhanced features for dataset analysis and biological discovery.

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Area of Science:

  • Bioinformatics
  • Molecular Biology
  • Genomics

Background:

  • The Gene Ontology (GO) provides essential functional annotations for gene products, rapidly expanding with biological data.
  • Efficiently mining this functional information is crucial for biological research.

Purpose of the Study:

  • To introduce QuickGO, a redeveloped web-based tool for browsing the Gene Ontology (GO) and associated annotations.
  • To demonstrate how QuickGO's enhanced features can assist researchers in analyzing datasets and directing biological research.

Main Methods:

  • QuickGO offers a fast, web-based interface for accessing GO terms and GO Annotation (GOA) data.
  • The tool has undergone redevelopment to incorporate advanced features beyond basic browsing.

Main Results:

  • QuickGO provides access to over 27,000 GO terms and associated gene product annotations.
  • User feedback highlights the tool's usefulness and positive reception after its redevelopment.

Conclusions:

  • QuickGO is a valuable resource for researchers needing to explore functional genomics data.
  • The tool's enhanced capabilities support deeper biological insights and research direction.