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Novel treatment approach to combat an infection with Acinetobacter

Jeffrey S Stroup1, Kendal Mitchell, David Hitzeman

  • 1Department of Medicine, Oklahoma State University Center for Health Sciences, Tulsa, Oklahoma.

Proceedings (Baylor University. Medical Center)
|February 17, 2010
PubMed

Insights

Multidrug-resistant Acinetobacter infections pose a significant challenge. A successful treatment involved high-dose doripenem combined with tigecycline and colistin for a resistant Acinetobacter case.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Pharmacology

Background:

  • Antimicrobial resistance in Gram-negative pathogens, particularly Pseudomonas spp. and Acinetobacter spp., is a growing clinical concern.
  • Standard antimicrobial doses are often ineffective against highly resistant strains, necessitating alternative therapeutic strategies.

Purpose of the Study:

  • To report a successful treatment of a multidrug-resistant Acinetobacter infection in an intensive care unit (ICU) patient.
  • To highlight the efficacy of a combination therapy involving high-dose doripenem.

Main Methods:

  • A case report of a patient in the ICU with a resistant Acinetobacter infection.
  • Treatment administered: doripenem (1 g every 8 hours) infused over 4 hours, combined with tigecycline and colistin.

Main Results:

  • Successful eradication of the resistant Acinetobacter infection.
  • The combination therapy was well-tolerated by the patient.

Conclusions:

  • High-dose doripenem combined with tigecycline and colistin can be an effective treatment option for severe, multidrug-resistant Acinetobacter infections.
  • This therapeutic approach may be valuable when standard treatments fail.

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