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Related Experiment Video

Updated: Jun 16, 2026

4D Imaging of Protein Aggregation in Live Cells

4D Imaging of Protein Aggregation in Live Cells

Published on: April 5, 2013

"Shping 2" different cellular localizations - a potential new player in aging processes.

Sascha Jakob¹, Joachim Altschmied, Judith Haendeler

¹Department of Molecular Cell & Aging Research, IUF at the University of Duesseldorf gGmbH, 40225 Duesseldorf, Germany.

|February 17, 2010

Summary

Protein tyrosine phosphatase Shp-2 localization dictates its function, impacting cell growth, inflammation, and aging. Nuclear and mitochondrial Shp-2 regulate gene transcription and cellular redox balance, suggesting a role in aging processes.

Keywords:

Shp-2 Telomerase Reverse Transcriptase mitochondria nucleus

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Published on: January 30, 2019

Area of Science:

Cell Biology
Biochemistry
Molecular Biology

Background:

Protein tyrosine phosphatase Shp-2 (Shp-2) is ubiquitously expressed.
Shp-2 functions are critically dependent on its subcellular localization.
Cytosolic Shp-2 regulates pathways for cell growth, development, inflammation, and chemotaxis.

Purpose of the Study:

To investigate the distinct roles of Shp-2 in the nucleus and mitochondria.
To explore the involvement of Shp-2 in gene transcription, cellular redox balance, and aging.

Main Methods:

The study reviews existing literature on Shp-2 localization and function.
Analysis of Shp-2 interactions with STAT5, STAT1, Src kinases, and Telomerase Reverse Transcriptase (TERT).
Discussion of Shp-2's role in regulating reactive oxygen species and respiratory chain activity.

Main Results:

Nuclear Shp-2 forms complexes with STAT5 to regulate gene transcription and dephosphorylates STAT1, inhibiting transcription.
Shp-2 counteracts Src kinase-mediated nuclear export of TERT, preventing replicative senescence.
Mitochondrial Shp-2 is implicated in regulating cellular redox balance, reactive oxygen species, and potentially respiratory chain activity.

Conclusions:

Shp-2 exhibits diverse functions based on its location within the cell.
Mitochondrial Shp-2 may positively regulate TERT, similar to its nuclear function.
Shp-2 emerges as a significant factor in cellular aging processes.