Donation of eggs in assisted reproduction and informed consent

In Spain, there exists an increasing amount of advertising for the donation of eggs for assisted reproduction. This study attempts to assess: (1) scientific evidence available about adverse effects of egg donation; (2) characteristics of the information given in the informed consent to donors; and (3) the legality of this advertising. The main results are: (1) Many severe problems are associated with induction of ovulation, as ovarian hyperstimulation (reported frequencies from 5.9 to 15%), thromboembolism, hepatic failure and increased risk of ovarian, breast, endometrial and colon cancer. (2) Informed consent for egg donors is very incomplete, according to the Spanish law 41/2002 on Patient's Information. (3) Current advertising to promote egg donation does not respect, among others, law 14/2006 about Assisted Human Reproduction, as it includes reference to economic compensation or benefits but no information about the risks. Deontological and judicial disciplinary procedures should be initiated to protect donors' rights.