Related Experiment Videos
Association between vitamin B12 levels and mortality in hospitalized older adults
Sari Tal1, Yoav Shavit, Felicia Stern
1Geriatrics Department, Kaplan Medical Center, Rehovot, Israel. mail@tal.org.il
Objectives:
To investigate the effect of various medications on vitamin B12 status and the association between vitamin B12 levels and mortality.
Design:
Retrospective cross-sectional study.
Setting:
Four internal medicine departments and the geriatrics department at Kaplan Medical Center (KMC), Rehovot and Harzfeld Geriatrics Hospital, Gedera, Israel.
Participants:
One thousand five hundred seventy patients aged 65 and older hospitalized at the KMC and Hartzfeld Hospital in 2007.
Measurements:
Blood vitamin B12 levels and demographic, clinical, and laboratory data obtained from electronic medical records.
Results:
Vitamin B12 deficiency (
Conclusion:
Higher vitamin B12 levels were associated with greater mortality, but it is unclear whether vitamin B12 is a marker or a surrogate marker or even a substance that directly causes death. Further investigation is needed to clarify.
Related Concept Videos
Vitamins
Development of Human Microbiota
Role of Vitamins in Maintaining Bone Health
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Pharmacodynamics in Geriatric Patients: Effects of Age
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption