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Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
CD203c expression on human basophils is associated with asthma exacerbation
Emiko Ono1, Masami Taniguchi, Noritaka Higashi
1Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Sagamihara, Japan; Division of Third Department of Internal Medicine, Oita University Faculty of Medicine, Yufu, Oita 879-5593, Japan. onoemii@e-ml.jp
The Journal of Allergy and Clinical Immunology
|February 18, 2010
Summary
CD203c, a basophil marker, is significantly higher during asthma exacerbations and decreases during remission. This suggests CD203c expression can monitor asthma control in patients.
Area of Science:
- Immunology
- Allergy Research
- Respiratory Medicine
Background:
- CD203c is a basophil cell surface marker utilized in diagnosing and monitoring allergic diseases.
- The specific relationship between CD203c expression and asthma, particularly its exacerbations, remains unclear.
Purpose of the Study:
- To investigate the association between CD203c expression levels and both stable and exacerbated asthma conditions.
- To determine if CD203c can serve as a biomarker for asthma status.
Main Methods:
- Flow cytometry was employed to compare spontaneous and stimulated basophil surface marker expression in patients with stable asthma, exacerbated asthma, and healthy controls.
- Longitudinal measurements assessed changes in CD203c expression following IgE-dependent and IgE-independent basophil stimulation in relation to asthma status.
Main Results:
- Spontaneous CD203c expression was significantly elevated on basophils during asthma exacerbations compared to stable asthma or healthy individuals.
- Anti-IgE, Dermatophagoides pteronyssinus, and IL-3 stimulation induced higher CD203c expression during exacerbations, correlating with asthma control.
- A negative correlation was observed between spontaneous CD203c levels and FEV(1) in patients experiencing clinical improvement.
Conclusions:
- Increased basophil CD203c expression is linked to asthma exacerbation and significantly decreases during remission.
- Basophil CD203c levels show potential as a monitoring tool for asthma control and disease activity.
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