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Related Concept Videos

Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
Drug Dependence01:17

Drug Dependence

Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...

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Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience
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Published on: August 26, 2014

Genetics of addictions.

Sarah M Hartz1, Laura J Bierut

  • 1Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110-1093, USA.

The Psychiatric Clinics of North America
|February 18, 2010
PubMed
Summary
This summary is machine-generated.

Addictions are common, heritable psychiatric illnesses with genetic links to various conditions. Understanding addiction genetics is crucial due to shared genetic factors with medical and psychiatric comorbidities.

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Area of Science:

  • Psychiatry
  • Genetics
  • Epidemiology

Background:

  • Addictions are prevalent, heritable psychiatric disorders.
  • They frequently co-occur with other psychiatric and medical conditions (comorbidities).
  • Genetic factors play a significant role in the development of addiction.

Purpose of the Study:

  • To review the genetic associations of common addictive disorders.
  • To explore shared genetic links between substance dependence and associated medical/psychiatric conditions.
  • To emphasize the importance of a comprehensive genetic understanding of addiction.

Main Methods:

  • Literature review of genetic association studies.
  • Analysis of common genetic factors across different addictions.
  • Examination of comorbidities linked to substance dependence.

Main Results:

  • Robust genetic associations identified for alcohol, nicotine, and cocaine dependence.
  • Shared genetic factors found between alcohol dependence and aerodigestive cancers.
  • Common genetic links observed between nicotine dependence and lung disease.

Conclusions:

  • Genetic underpinnings of addiction are complex and intertwined with other diseases.
  • Understanding these genetic connections is vital for managing addiction and its consequences.
  • Further research into shared genetics can inform prevention and treatment strategies.