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Adrenocortical function in aging exercise-trained rats.

J A Severson, R D Fell, J G Tuig

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |November 1, 1977
    PubMed
    Summary
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    Exercise training alters rat responses to acute swimming stress. While young trained rats show higher corticosterone, older trained rats exhibit lower levels, suggesting age-dependent adaptations in stress hormone regulation.

    Area of Science:

    • Endocrinology
    • Exercise Physiology
    • Stress Response

    Background:

    • Exercise training is known to influence the endocrine system.
    • The pituitary-adrenal axis plays a crucial role in the stress response.

    Purpose of the Study:

    • To investigate the effects of chronic exercise training on plasma corticosterone levels and adrenal responsiveness in rats of different ages subjected to acute swimming stress.
    • To explore potential mechanisms, including extra-adrenal factors, influencing these responses.

    Main Methods:

    • Rats of three age groups (100, 200, 300 days) underwent a 10-week treadmill running training program.
    • Following training, rats were exposed to an acute swimming stress test.
    • Plasma corticosterone concentrations were measured.

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  • In vitro adrenal gland responsiveness to adrenocorticotropic hormone was assessed.

    • Main Results:

    • Acute swimming elevated plasma corticosterone in all age groups.
    • At 170 days, trained rats showed higher post-swim corticosterone than controls; at 270 and 370 days, the opposite was observed.
    • Acute swimming enhanced in vitro adrenal response to ACTH in controls and 170-day-old trained rats.

    Conclusions:

    • Age and exercise training interact to modulate the pituitary-adrenal response to acute swimming stress.
    • Both adrenal sensitivity and extra-adrenal mechanisms, potentially involving decreased corticosterone turnover, contribute to plasma corticosterone regulation during stress.