Related Experiment Video
Updated: Jun 16, 2026

Identification of Quiescent Cells in a Zebrafish T-Cell Acute Lymphoblastic Leukemia Model Using Cell Proliferation Staining
Published on: July 19, 2024
ZEB proteins link cell motility with cell cycle control and cell survival in cancer
Gareth Browne1, A Emre Sayan, Eugene Tulchinsky
1Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK.
Abstract:
Epithelial mesenchymal transitions (EMT), the generation of motile mesenchymal cells from epithelial sheets, are differentiation programs which take place at several critical steps of embryonic development and in metastatic cancer. Recent data have shown that the transcription factors which are master regulators of EMT also regulate cell cycle progression, apoptosis and senescence. In light of these new observations, the role of these factors in human cancer may be broader than previously anticipated. Here we review recent literature on non-EMT functions of EMT-controlling transcription factors. We will mainly focus on transcription factors belonging to the ZEB family, but some important results obtained by investigators studying other key EMT regulators, Snail and Twist are also discussed.
Related Concept Videos
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
Negative Regulator Molecules
Cancer Cell Migration through Invadopodia
Cell Motility through Blebbing
Blebbing Through the Matrix
In multicellular...
Inhibition of Cdk Activity
Mitogens and the Cell Cycle

