Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least squares (OLS)...
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
Model Approaches for Pharmacokinetic Data: Physiological Models01:15

Model Approaches for Pharmacokinetic Data: Physiological Models

Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
Pharmacodynamic Models: Additive and Proportional Drug Effect Model01:09

Pharmacodynamic Models: Additive and Proportional Drug Effect Model

Drug response models describe how pharmacological agents interact with biological systems to produce measurable effects. Baseline responses are inherent physiological activities without a drug significantly influencing the observed pharmacological outcomes. Depending on the drug response model employed, these baseline responses may combine with the drug's effect in either an additive or proportional manner.Additive Drug Response ModelIn the additive model, the drug effect is independent of the...
Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches01:14

Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches

Drug disposition in the body is a complex process and can be studied using two major approaches: the model and the model-independent approaches.
The model approach uses mathematical models to describe changes in drug concentration over time. Pharmacokinetic models help characterize drug behavior in patients, predict drug concentration in the body fluids, calculate optimum dosage regimens, and evaluate the risk of toxicity. However, ensuring that the model fits the experimental data accurately...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Community Reinforcement and Family Training (CRAFT) goes digital: Randomized pilot trial for families of individuals with opioid use problems.

Experimental and clinical psychopharmacology·2026
Same author

How predator evolution to resist lethal or sublethal toxicant effects impact the dynamics of a discrete-time predator-prey system.

Journal of biological dynamics·2025
Same author

Registration and multiple outcome testing in the HEALing communities study.

The International journal on drug policy·2025
Same author

A SPATIALLY-EXPLICIT STOCHASTIC MODEL FOR THE GULF COAST TICK.

Ecological modelling·2025
Same author

Impact of redefining statistical significance on P-hacking and false positive rates: An agent-based model.

PloS one·2024
Same author

The interplay between multiple control mechanisms in a host-parasitoid system: a discrete-time stage-structured modelling approach.

Journal of biological dynamics·2023
Same journal

Analysis and control of an SEIR epidemic system with nonlinear transmission rate.

Mathematical and computer modelling·2020
Same journal

Periodic solutions and bifurcation in an <math></math> epidemic model with birth pulses.

Mathematical and computer modelling·2020
Same journal

Optimal and sub-optimal quarantine and isolation control in SARS epidemics.

Mathematical and computer modelling·2020
Same journal

A discrete epidemic model for SARS transmission and control in China.

Mathematical and computer modelling·2020
Same journal

BIFURCATING DISTRIBUTIVE SYSTEM USING MONTE CARLO METHOD.

Mathematical and computer modelling·2012
Same journal

An Adaptive Multigrid Algorithm for Simulating Solid Tumor Growth Using Mixture Models.

Mathematical and computer modelling·2010
See all related articles

Related Experiment Video

Updated: Jun 16, 2026

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis
08:45

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Published on: November 8, 2024

Ecosystem Modeling of College Drinking: Parameter Estimation and Comparing Models to Data.

Azmy S Ackleh1, Ben G Fitzpatrick, Richard Scribner

  • 1Department of Mathematics, University of Louisiana at Lafayette, Lafayette, LA 70504.

Mathematical and Computer Modelling
|February 18, 2010
PubMed
Summary
This summary is machine-generated.

We developed a novel method to estimate parameters for a model of college student drinking patterns. Reducing campus "wetness" effectively decreases binge drinking, unlike penalizing students.

More Related Videos

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
07:31

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Published on: January 7, 2019

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

Related Experiment Videos

Last Updated: Jun 16, 2026

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis
08:45

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Published on: November 8, 2024

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
07:31

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Published on: January 7, 2019

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

Area of Science:

  • Mathematical modeling
  • Epidemiology
  • Public health

Background:

  • College student drinking persists at epidemic levels.
  • Accurate predictive models require precise parameter estimation.
  • Standard parameter estimation methods were insufficient for this model.

Purpose of the Study:

  • To present an unconventional parameter estimation approach for a drinking behavior model.
  • To validate the model's fit with real-world survey data.
  • To evaluate the impact of hypothetical intervention strategies.

Main Methods:

  • Developed a model of college student drinking using five impulsive differential equations.
  • Employed an unconventional inverse problem approach for parameter estimation.
  • Utilized survey data from 32 college campuses for model fitting and validation.

Main Results:

  • The developed model demonstrated a good fit to survey data across 32 campuses.
  • Parameter estimation was successfully achieved using the novel approach.
  • Simulations indicated that reducing campus "wetness" significantly reduces binge drinking.

Conclusions:

  • The unconventional parameter estimation method is effective for this complex model.
  • Reducing environmental factors contributing to drinking ("wetness") is a promising intervention strategy.
  • Policies penalizing student drinkers are less effective than environmental interventions for reducing binge drinking.