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Published on: June 18, 2012
Construction of an N-nitroso database for assessing dietary intake
Janice E Stuff1, Eugenia T Goh, Stephanie L Barrera
1Assistant Professor, Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, 1100 Bates, Houston, TX 77030.
Researchers developed a comprehensive database to quantify dietary N-nitroso compound intake, crucial for understanding cancer risks. This tool aids epidemiological studies by providing accurate N-nitroso levels in foods like processed meats.
Area of Science:
- Food Science
- Toxicology
- Epidemiology
Background:
- Dietary N-nitroso compounds are carcinogens formed during food processing.
- Accurate quantification of intake is vital for studying human cancers, including stomach, colon, and brain cancers.
- Previous research relied on proxy estimates, lacking a complete N-nitroso compound database.
Purpose of the Study:
- To develop a comprehensive database of N-nitroso compounds in foods.
- To enable accurate quantification of dietary N-nitroso compound intake.
- To support cancer epidemiological studies.
Main Methods:
- Compiled and evaluated published analytical data for N-nitroso compounds.
- Created a database of 23 N-nitroso compounds across 500 foods from 39 subgroups.
- Matched database foods to a standard food frequency questionnaire (FFQ).
Main Results:
- The database includes N-nitroso values for 500 foods.
- N-nitroso content ranged from <0.01 to 142 microg/100 g.
- Richest sources identified as sausage, smoked meats, bacon, and luncheon meats.
Conclusions:
- The developed database accurately quantifies N-nitroso intake.
- It is a valuable tool for observational and epidemiological cancer studies.
- Improved dietary N-nitroso data can enhance understanding of diet-cancer relationships.
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