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Related Concept Videos

Drug Products: Biologics, Biosimilars and Interchangeables01:28

Drug Products: Biologics, Biosimilars and Interchangeables

Biologics, derived from living sources such as humans, animals, or microorganisms, represent a significant category of pharmaceuticals. These complex molecules, developed through advanced biotechnological methods or purified from natural sources, include essential medical treatments like insulin and growth hormones. The complexity of biologics arises from their large molecular structures and the intricate processes required for their production, making them distinct from conventional...
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...
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Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
Microorganisms in Medicine and Therapeutics01:29

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...

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Related Experiment Video

Updated: Jun 16, 2026

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
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Published on: January 24, 2025

Biologics in dermatologic therapy - an update.

Arijit Coondoo1

  • 1Department of Dermatology, Vivekananda Institute of Medical Science, Kolkata, India.

Indian Journal of Dermatology
|February 18, 2010
PubMed
Summary
This summary is machine-generated.

Biologics, manufactured using recombinant DNA technology, offer targeted treatment for diseases by acting on specific immunopathogenesis points. These protein molecules demonstrate fewer side effects compared to traditional immunosuppressives due to their precise mechanism of action.

Keywords:
Biologicsgranulocyte macrophageinterferoninterleukin

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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

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Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Area of Science:

  • Immunology
  • Biotechnology
  • Dermatology

Background:

  • Biologics are protein molecules produced via recombinant DNA technology.
  • They target specific points in disease immunopathogenesis.
  • Traditional immunosuppressives have broader action and more side effects.

Purpose of the Study:

  • To discuss the role and benefits of biologics in disease treatment.
  • To highlight the advantages of biologics over conventional immunosuppressive therapies.
  • To review the impact of biologics in managing dermatologic diseases.

Main Methods:

  • Review of biologics produced by recombinant DNA technology.
  • Analysis of the targeted action of biologics on specific immunopathogenesis pathways.
  • Comparison of the side-effect profiles of biologics versus traditional immunosuppressives.

Main Results:

  • Biologics bind to specific targets, minimizing interference with other pathways.
  • Biologics exhibit significantly fewer side effects compared to broader-acting immunosuppressives.
  • Biologics have revolutionized the treatment landscape for various dermatologic conditions.

Conclusions:

  • Biologics represent a targeted and safer therapeutic option.
  • Their specific action leads to improved patient outcomes with reduced adverse events.
  • Biologics have transformed the management of immune-mediated diseases, particularly in dermatology.