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Mucocutaneous changes in tuberous sclerosis complex: a clinical profile of 27 Indian patients
Sudip Kumar Ghosh1, Debabrata Bandyopadhyay, Gobinda Chatterjee
1Departments of Dermatology, Venereology and Leprosy, R.G.Kar Medical College, Kolkata, India.
Background:
Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous disease resulting in a wide array of clinical manifestations, primarily affecting the skin and central nervous system. Mucocutaneous features play a very important role in the recognition of this syndrome.
Aims:
To review the prevalence and patterns of cutaneous manifestations in tuberous sclerosis, in a group of patients from eastern India.
Methods:
Observational clinical study on twenty-seven consecutive patients of tuberous sclerosis collected during a period of four years.
Results:
Most were between 10-20 years of age; the male to female ratio was 2:1. Family history was found in two-thirds. The classical triad of tuberous sclerosis was present in only nine (33.3%) patients. Adenoma sebaceum was the most common cutaneous feature (100%), followed by hypomelanotic macules (92.6%), connective tissue nevi (66.6%), and Koenen's tumors (33.3%). Oral mucosal fibromas were seen in six (22.22%) patients. Fibromatous plaque over forehead and scalp was seen in three patients. Limitation of the study was small size of study sample.
Conclusion:
Prominent mucocutaneous changes are extremely common manifestation of TSC, which may provide crucial diagnostic clues for primary care physicians.
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