Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction notice to"Nitric oxide sensing by chlorophyll a" [Anal. Chim. Acta 985 (2017) 101-113].

Analytica chimica acta·2026
Same author

Synergy of Rectangular Truncated Highly Reactive Facets of the Functional Heterometallic Oxo Cage for Enhanced Decomposition of Paraoxon.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

IgE based therapeutics are an emerging modality in cancer treatment.

Discover oncology·2025
Same author

Corrigendum to "Detection and proteomic identification of in vivo S-nitrosylated proteins in Vibrio cholerae: A novel evidence" [Nitric Oxide 159 (2025) 63-77].

Nitric oxide : biology and chemistry·2025
Same author

Detection and proteomic identification of in vivo S-nitrosylated proteins in Vibrio cholerae: A novel evidence.

Nitric oxide : biology and chemistry·2025
Same author

A Rational Design Strategy for Engineering CH4 Domain of IgE for Heterodimerization.

Biotechnology and bioengineering·2025
Same journal

Severe Irritant Contact Dermatitis to <i>Cyperus Scariosus</i>: A Side Effect of Ayurvedic <i>Plava</i>.

Indian journal of dermatology·2026
Same journal

Extensive Grouped Papules on the Vulva in a Patient with Cervical Cancer.

Indian journal of dermatology·2026
Same journal

Facial Melanosis: A Comprehensive Review of Uncommon and Common Presentations with Personal Experience.

Indian journal of dermatology·2026
Same journal

Exploring AI as a Diagnostic Tool in Medical Imaging for Dermatopathological Diseases.

Indian journal of dermatology·2026
Same journal

Carotid Intima-Media Thickness and Retrobulbar Blood Flow in Patients with Psoriasis.

Indian journal of dermatology·2026
Same journal

Pyoderma Gangrenosum-Like Ulcer Secondary to Antiphospholipid Syndrome.

Indian journal of dermatology·2026
See all related articles

Related Experiment Video

Updated: Jun 16, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

What'S new in urticaria?

Sanjay Ghosh1

  • 1Urticaria Clinic, Institute of Allergic and Immunological Skin Diseases, Kolkata, India.

Indian Journal of Dermatology
|February 18, 2010
PubMed
Summary
This summary is machine-generated.

Urticaria research is rapidly evolving, revealing new insights into its mechanisms and treatment. Emerging evidence highlights coagulation disorders, bradykinin angioedema, H. pylori, and vasculitis as key factors, with promising treatments like omalizumab.

Keywords:
NB UVBUrticaiaangiedemaomalizumabquality of lifeurticaria multiforme

More Related Videos

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

Related Experiment Videos

Last Updated: Jun 16, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

Area of Science:

  • Dermatology
  • Immunology
  • Internal Medicine

Background:

  • Urticaria presents complex challenges with evolving understanding and significant impact on quality of life.
  • Rising treatment costs necessitate a deeper understanding of urticaria's underlying mechanisms.

Purpose of the Study:

  • To review recent advancements in understanding urticaria pathogenesis.
  • To explore novel diagnostic findings and therapeutic approaches for various urticaria forms.

Main Methods:

  • Literature review of recent global findings on urticaria.
  • Analysis of potential etiological factors including coagulation, bradykinin, H. pylori, and vasculitis.
  • Evaluation of diagnostic tools like skin biopsy and contact sensitization tests.

Main Results:

  • Coagulation cascade disorders and bradykinin-induced angioedema are implicated in urticaria mechanisms.
  • Helicobacter pylori's role in pathogenesis is under re-evaluation.
  • Urticaria multiforme and vasculitic changes on skin biopsy are noted.
  • Contact sensitization and positive results indicate contact urticaria.

Conclusions:

  • Urticaria is a dynamic condition with diverse underlying mechanisms.
  • Newer therapeutic strategies including topical clobetasol, systemic omalizumab, and NB UVB show promise for specific urticaria types.