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Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
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Saccade suppression by electrical microstimulation in monkey caudate nucleus.

Masayuki Watanabe1, Douglas P Munoz

  • 1Centre for Neuroscience Studies, Queen's University, Kingston, Ontario K7L 3N6, Canada.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|February 19, 2010
PubMed
Summary
This summary is machine-generated.

The caudate nucleus directly suppresses saccades by slowing reaction times, influencing eye movement decisions. This research clarifies the caudate nucleus's role in saccadic control.

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Area of Science:

  • Neuroscience
  • Oculomotor control
  • Basal ganglia function

Background:

  • The caudate nucleus, a key part of the basal ganglia, is implicated in controlling eye movements.
  • Previous studies suggested its role in saccade facilitation, but its involvement in saccade suppression remained unclear.

Purpose of the Study:

  • To investigate the direct role of the caudate nucleus in saccade suppression.
  • To understand how electrical microstimulation of the caudate nucleus affects saccade initiation and performance.

Main Methods:

  • Electrical microstimulation was applied to the caudate nucleus in behaving monkeys.
  • Monkeys performed prosaccade and antisaccade tasks.
  • Reaction times and performance rates were analyzed using the LATER model.

Main Results:

  • Microstimulation of the caudate nucleus prolonged reaction times for contralateral saccades in both prosaccade and antisaccade trials.
  • Suppression effects were more pronounced in prosaccade trials.
  • Microstimulation reduced the rate of rise to the saccade initiation threshold and worsened performance rates for contralateral saccades.
  • Effects on ipsilateral saccades were inconsistent.

Conclusions:

  • Caudate nucleus signals are sufficient to suppress contralateral saccades.
  • Caudate nucleus activity influences saccadic decision-making by modulating both contralateral and ipsilateral saccade commands.