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Related Concept Videos

Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...

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A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes
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Published on: February 17, 2023

Tropical diabetic hand syndrome.

Sangeeta Tiwari1, Ashutosh Chauhan, N T Sethi

  • 1Department of Surgery, Military Hospital, Ambala, India.

International Journal of Diabetes in Developing Countries
|February 19, 2010
PubMed
Summary
This summary is machine-generated.

Tropical diabetic hand syndrome (TDHS) is a severe hand infection in tropical diabetes patients. Aggressive glycemic control and surgery are crucial to prevent fatal outcomes.

Keywords:
Diabetesgangrenehandinfection

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Area of Science:

  • Tropical medicine
  • Endocrinology
  • Infectious diseases

Background:

  • Tropical diabetic hand syndrome (TDHS) is a severe complication of diabetes mellitus in tropical regions.
  • This syndrome is often under-recognized and under-reported, leading to delayed diagnosis and treatment.

Observation:

  • The study presents two cases of TDHS, illustrating its spectrum from localized cellulitis to fulminant sepsis.
  • Symptoms include hand swelling, ulceration, and potentially life-threatening infections.

Findings:

  • Aggressive glycemic control is essential for managing TDHS.
  • Prompt surgical intervention is critical to prevent severe complications.

Implications:

  • Early recognition and management of TDHS can prevent debilitating or fatal outcomes in diabetic patients.
  • Increased awareness and reporting of TDHS are needed in tropical healthcare settings.