Related Experiment Video
Updated: Jun 16, 2026

08:53
Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness
Published on: August 31, 2016
Preparing for growth: current capacity and challenges in hematopoietic stem cell transplantation programs
Jeffrey R Schriber1, Claudio Anasetti, Helen E Heslop
1Department of Blood and Marrow Transplantation, Banner Health, Phoenix, Arizona, USA.
Summary
Demand for hematopoietic stem cell transplantation is rising. Current centers can only increase patient volume by approximately 7%, necessitating resource investment for future growth.
Area of Science:
- Hematology
- Transplantation Medicine
- Health Services Research
Background:
- The demand for hematopoietic stem cell transplantation (HSCT) has significantly increased over the last decade.
- Future projections indicate a continued or accelerated rise in HSCT demand.
Purpose of the Study:
- To assess the current patient capacity of HSCT programs.
- To determine the potential elasticity of existing transplantation centers to accommodate increased patient volumes.
- To identify resource needs for expanding HSCT services.
Main Methods:
- An informal survey was conducted among medical directors of HSCT programs.
- The survey aimed to gather data on current patient capacity and potential for expansion.
Main Results:
- Existing HSCT facilities have a limited capacity to increase patient volume, estimated at approximately 7%.
- Significant expansion beyond this capacity requires substantial resource infusion.
Conclusions:
- Current HSCT infrastructure has limited ability to meet escalating demand.
- Substantial investment in resources is crucial for expanding existing programs or establishing new ones to meet future needs.
Related Concept Videos
Multipotency of Hematopoietic Stem Cells
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Regulation of Hematopoietic Stem Cells
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Stem Cell Therapy for Tissue Regeneration
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Hematopoiesis
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Role of Hematopoietic Growth Factors
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Thrombopoietin (TPO), mainly released by the liver,...

