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Updated: Jun 16, 2026
07:37
Translational Orthotopic Models of Glioblastoma Multiforme
Published on: February 17, 2023
Pseudoprogression following chemoradiotherapy for glioblastoma multiforme
Paul Sanghera1, James Perry, Arjun Sahgal
1Odette Cancer Centre, University of Toronto, Ontario, Canada.
Summary
Pseudoprogression (psPD) after glioblastoma radiotherapy with temozolomide (RT/TMZ) occurs in about one-third of early progression cases. Patients with psPD show significantly better survival, indicating continued treatment is beneficial.
Area of Science:
- Neuro-oncology
- Radiation oncology
- Clinical trials
Background:
- Pseudoprogression (psPD) is a recognized phenomenon after radiotherapy with concurrent temozolomide (RT/TMZ) for glioblastoma multiforme (GBM).
- Distinguishing psPD from true tumor progression is critical for patient management.
Purpose of the Study:
- To determine the incidence of psPD following RT/TMZ in GBM patients.
- To evaluate the impact of psPD on patient prognosis and overall survival.
Main Methods:
- Retrospective review of clinical and radiographic data from 111 newly diagnosed GBM patients treated with RT/TMZ.
- Definition of early progression and psPD based on RECIST criteria and subsequent disease stabilization.
- Overall survival analysis using Kaplan-Meier and log rank tests.
Main Results:
- 104 patients were evaluable for radiological response; 26% showed early progression.
- Within the early progression group, 32% were classified as psPD.
- Median survival for psPD patients (124.9 weeks) was significantly higher than for true early progression patients (36.0 weeks).
Conclusions:
- Approximately one-third of GBM patients exhibiting early progression after RT/TMZ actually have psPD.
- psPD is associated with a favorable prognosis, suggesting maintenance TMZ should not be discontinued based solely on early imaging findings.
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