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[Fixed food eruption caused by liquorice].

S Benomar1, N Ismaili, J Koufane

  • 1Service de dermatologie, hôpital Ibn Sina, place Beniznassen, Souissi, Rabat, Maroc. sophiabenomar@yahoo.fr

Annales De Dermatologie Et De Venereologie
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Summary

This study details a rare case of fixed food eruption caused by liquorice. This adverse reaction, typically linked to medications, highlights liquorice as a potential dietary trigger.

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Area of Science:

  • Dermatology
  • Allergology
  • Pharmacovigilance

Background:

  • Fixed drug eruption (FDE) is a distinct cutaneous reaction to medications, recurring at specific body sites.
  • While typically drug-induced, similar eruptions can be triggered by food, termed fixed food eruption (FFE).
  • This case investigates a potential link between dietary components and FDE-like reactions.

Observation:

  • A 22-year-old woman presented with a fixed drug reaction attributed to liquorice consumption.
  • Diagnostic evaluations, including topical challenges at affected and unaffected skin sites, yielded negative results.
  • The diagnosis was confirmed through therapeutic re-exposure to liquorice.

Findings:

  • This report documents the first known case of a fixed food eruption specifically caused by liquorice.
  • The reaction pattern mimicked a typical fixed drug eruption but was triggered by a food item.
  • Diagnostic challenges suggest a specific mechanism for this food-induced cutaneous reaction.

Implications:

  • Highlights liquorice as a potential, previously unrecognized trigger for fixed food eruptions.
  • Expands the differential diagnosis for fixed drug eruptions to include specific food substances.
  • Underscores the importance of detailed dietary history in evaluating cutaneous adverse reactions.