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Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
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Related Experiment Video

Updated: Jun 16, 2026

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
09:44

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

Radiation therapy and hearing loss.

Niranjan Bhandare1, Andrew Jackson, Avraham Eisbruch

  • 1Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida 32610, USA.

International Journal of Radiation Oncology, Biology, Physics
|February 23, 2010
PubMed
Summary
This summary is machine-generated.

This review examines sensorineural hearing loss after radiation therapy for head and neck tumors. Due to cochlear dose variability, specific limits are suggested to manage radiation therapy-associated ototoxicity.

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Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage
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Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage
07:13

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Published on: February 10, 2023

Area of Science:

  • Otolaryngology
  • Radiation Oncology
  • Neurosurgery

Background:

  • Sensorineural hearing loss (SNHl) is a common complication following radiation therapy for head and neck tumors and vestibular schwannoma.
  • The cochlea's small volume limits the utility of dose-volume analyses in predicting SNHL.
  • Existing literature focuses on mean cochlear dose and other factors influencing SNHL outcomes.

Purpose of the Study:

  • To review the literature on SNHL development after radiation therapy for head and neck tumors and vestibular schwannoma.
  • To evaluate the impact of mean cochlear dose and other factors on SNHL.
  • To propose dose-prescription limits and a standardized method for evaluating radiation therapy-associated ototoxicity.

Main Methods:

  • Literature review of studies on SNHL after radiation therapy for head and neck tumors and vestibular schwannoma.
  • Evaluation of mean cochlear dose, treatment parameters, and patient-related factors.
  • Analysis of existing standards for ototoxicity evaluation.

Main Results:

  • A specific dose threshold for SNHL could not be determined from the current literature.
  • Mean cochlear dose is a significant factor, but other variables also influence SNHL.
  • A need for standardized ototoxicity evaluation and dose-prescription limits is evident.

Conclusions:

  • Establishing precise dose thresholds for SNHL is challenging due to cochlear dose variability.
  • Dose-prescription limits and standardized ototoxicity scoring are recommended to mitigate SNHL risk.
  • Further research is needed to refine predictive models and management strategies for radiation-induced hearing loss.