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Intratracheal Inoculation of Fischer 344 Rats with Francisella tularensis
Published on: September 30, 2017
Tularemia pneumonia
Lora D Thomas1, William Schaffner
1Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, A2200 MCN, 1161 21st Avenue South, Nashville, TN 37232, USA. lora.thomas@vanderbilt.edu
Abstract:
Francisella tularensis is a zoonotic infection that can be acquired in multiple ways, including a bite from an arthropod, the handling of animal carcasses, consumption of contaminated food and water, or inhalation of infected particles. The most virulent subspecies of F tularensis is type A, which is almost exclusively seen in North America. Pneumonia can occur in tularemia, as either a primary process from direct inhalation, or as a secondary manifestation of ulceroglandular or typhoidal disease. This article describes the history of this infection, epidemiology, methods of diagnosis and treatment, and its potential as a bioterrorism weapon.
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