Related Experiment Video
Updated: Jun 16, 2026
08:41
Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
Severe acute respiratory syndrome (SARS).
Dennis J Cleri1, Anthony J Ricketti, John R Vernaleo
1Internal Medicine Residency Program, St Francis Medical Center, 601 Hamilton Avenue, Trenton, NJ 08629, USA. dcleri@StFrancisMedical.org
Infectious Disease Clinics of North America
|February 23, 2010
Summary
This review covers severe respiratory distress syndrome (ARDS), detailing its virology, history, pathology, and epidemiology. It also outlines clinical presentations, complications, diagnostic methods, and effective prevention strategies for ARDS.
Area of Science:
- Medicine
- Virology
- Pathology
Background:
- Severe respiratory distress syndrome (ARDS) is a critical medical condition with significant global health implications.
- Understanding the multifaceted nature of ARDS is crucial for effective management and control.
Purpose of the Study:
- To provide a comprehensive review of severe respiratory distress syndrome (ARDS).
- To cover all aspects of ARDS, including its virology, history, pathology, epidemiology, clinical features, complications, diagnostics, treatment, and prevention.
Main Methods:
- Literature review of documented outbreaks and scientific publications on ARDS.
- Synthesis of information on the virology, history, pathology, and epidemiology of ARDS.
- Compilation of data on clinical presentations, complications, radiology, laboratory testing, diagnosis, treatment, and prevention.
Main Results:
- ARDS presents with diverse clinical manifestations and potential complications.
- Effective diagnosis relies on a combination of clinical, radiological, and laboratory findings.
- Prevention strategies and treatment protocols are continually evolving.
Conclusions:
- A thorough understanding of ARDS across all its facets is essential for healthcare professionals.
- Continued research into ARDS virology, pathology, and treatment is vital.
- Public health measures and prompt medical intervention are key to managing ARDS outbreaks.
Related Concept Videos
01:29Coronavirus
Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...
01:29Respiratory Syncytial Virus Disease
Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
01:21Acute Respiratory Failure-I
Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
01:30Acute Respiratory Failure-III
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without causing...
01:21Acute Respiratory Failure-II
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...