Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
Increased Intracranial Pressure l: Introduction01:14

Increased Intracranial Pressure l: Introduction

Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Robotic-Assisted Electrode Insertion for Pediatric Cochlear Implantation: A Multicenter Study.

The Laryngoscope·2026
Same author

Frequent S100 and PAX8 expression in otitis media: Unexpected findings and potential sources of diagnostic confusion in middle ear pathology.

Annals of diagnostic pathology·2026
Same author

Rates of Hereditary Paraganglioma Syndromes and Secretory Head and Neck Paragangliomas: A Single-Institution Experience.

Journal of neurological surgery. Part B, Skull base·2026
Same author

Vestibular Dysfunction as a Novel Presentation of Middle Ear Neuroendocrine Tumor.

Journal of neurological surgery reports·2026
Same author

Ossiculoplasty in Focus: Integrating Fundamental Science with Complex Clinical Practice.

Otolaryngologic clinics of North America·2026
Same author

Imaging for Ossiculoplasty.

Otolaryngologic clinics of North America·2026

Related Experiment Video

Updated: Jun 16, 2026

Endoscopic Third Ventriculostomy and Pineal Biopsy from a Single Entry Point
03:13

Endoscopic Third Ventriculostomy and Pineal Biopsy from a Single Entry Point

Published on: June 28, 2024

Pediatric otogenic intracranial abscesses.

Brandon Isaacson1, Christine Mirabal, J Walter Kutz

  • 1Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75287, USA. Brandon.isaacson@utsouthwestern.edu

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|February 23, 2010
PubMed
Summary

Otogenic intracranial abscesses can be treated with antibiotics alone in select pediatric cases. Canal wall up mastoidectomy is a viable surgical option when intervention is needed.

Related Experiment Videos

Last Updated: Jun 16, 2026

Endoscopic Third Ventriculostomy and Pineal Biopsy from a Single Entry Point
03:13

Endoscopic Third Ventriculostomy and Pineal Biopsy from a Single Entry Point

Published on: June 28, 2024

Area of Science:

  • Pediatric Otolaryngology
  • Neurosurgery
  • Infectious Diseases

Background:

  • Otogenic intracranial abscesses are severe complications of otitis media.
  • Prompt diagnosis and management are crucial for favorable outcomes.

Purpose of the Study:

  • To describe the clinical presentation and management strategies for otogenic intracranial abscesses in children.
  • To evaluate the effectiveness of different treatment approaches, including surgical and non-surgical options.

Main Methods:

  • Retrospective case series and chart review of pediatric patients.
  • Inpatient database query for specific diagnostic codes related to otitis media complications.
  • Analysis of presenting symptoms, microbiology, treatment modalities, and patient outcomes.

Main Results:

  • Forty pediatric patients with otogenic intracranial complications were identified.
  • Thirty patients had suppurative complications (intraparenchymal, epidural, subdural, or petrous apex abscesses).
  • Treatment included canal wall up mastoidectomy (80%), craniotomy (10%), or intravenous antibiotics (10%); no mortalities were observed.

Conclusions:

  • Selected pediatric patients with intracranial abscesses may be managed non-surgically with intravenous antibiotics.
  • Canal wall up mastoidectomy is an acceptable surgical alternative to radical mastoidectomy for otogenic intracranial complications.