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Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients
13:50

Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients

Published on: June 11, 2011

[Spectrum of cardiovascular disease in HIV-infected patients]

Fernando Lozano1

  • 1Unidad Clínica de Enfermedades Infecciosas, Hospital Universitario de Valme, Sevilla, España. fernandolozano@telefonica.net

Enfermedades Infecciosas Y Microbiologia Clinica
|February 23, 2010
PubMed

Insights

HIV infection significantly increases the risk of arteriosclerotic cardiovascular disease in all patients. This heightened risk is linked to HIV itself, traditional factors, and certain medications.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Vascular Medicine

Context:

  • HIV infection is associated with an elevated risk of arteriosclerotic cardiovascular disease (ASCVD).
  • Evidence spans clinical manifestations like heart attack and stroke, and subclinical markers of atherosclerosis and endothelial dysfunction.
  • Studies assess various arterial beds (carotid, coronary, peripheral) using diverse diagnostic methods.

Purpose:

  • To summarize the evidence linking HIV infection to increased ASCVD risk.
  • To identify key contributors to this excess cardiovascular risk in HIV-positive individuals.

Summary:

  • HIV-infected patients exhibit a higher incidence of ASCVD, including myocardial infarction, stroke, and peripheral arterial disease.
  • Premature atherosclerosis and endothelial dysfunction markers are frequently observed in HIV-positive individuals.
  • Excess ASCVD risk is primarily attributed to HIV infection and traditional cardiovascular risk factors, with a lesser contribution from early protease inhibitors.

Impact:

  • Highlights the critical need for cardiovascular risk assessment and management in HIV care.
  • Informs clinical practice regarding the specific cardiovascular threats faced by the HIV-positive population.
  • Underscores the importance of addressing both HIV-specific and general cardiovascular risk factors.

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