Related Experiment Video
Updated: Jun 16, 2026

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
Published on: August 2, 2016
Effect of molecular weight on the oleoyl-chitosan nanoparticles as carriers for doxorubicin
Jing Zhang1, Xi Guang Chen, Gang Zheng Sun
1College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao, 266003, PR China.
Abstract:
Self-assembled oleoyl-chitosan (OCH) nanoparticles based on chitosan with different molecular weights (5kDa, 38kDa and 300kDa) were prepared by oil/water (O/W) emulsification method. The nanoparticles have spherical shape and the mean diameters were 131.8nm, 255.3nm and 334.1nm, respectively. Doxorubicin hydrochloride (DOX) was efficiently loaded into OCH nanoparticles and shown to be sustained release in PBS. The loading efficiency and the DOX release rate increased as the molecular weight of chitosan decreased. The blank OCH nanoparticles showed no cytotoxicity to mouse embryo fibroblasts and human lung cancer cell line A549. The inhibitory rates of DOX-loaded OCH nanoparticle suspension to A549 cells significantly outperformed that of DOX solution, and decreased with the increase of molecular weight. These results revealed the promising potential of low molecular weight OCH nanoparticles as carriers for antitumor agents.
More Related Videos
09:03Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
08:57Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
Published on: October 5, 2017
Related Concept Videos
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Factors Affecting Dissolution: Particle Size and Effective Surface Area