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From Constructs to Crystals – Towards Structure Determination of β-barrel Outer Membrane Proteins
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Structure and assembly of pore-forming proteins

Ioan Iacovache1, Mirko Bischofberger, F Gisou van der Goot

  • 1Ecole Polytechnique Fédérale de Lausanne, Global Health Institute, Station 15, Lausanne, Switzerland.

Current Opinion in Structural Biology
|February 23, 2010
PubMed
Summary

Pore-forming proteins assemble into transmembrane pores for host-pathogen interactions. These ancient proteins utilize conserved mechanisms across diverse organisms, from bacteria to mammals.

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