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Updated: Jun 16, 2026
Creation of Two Saccular Elastase-Digested Aneurysms with Different Hemodynamics in One Rabbit
Published on: April 15, 2021
Differential expression of genes in elastase-induced saccular aneurysms with high and low aspect ratios
Ramanathan Kadirvel1, Yong-Hong Ding, Daying Dai
1Neuroradiology Research Laboratory, Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
Background:
Morphologic features are thought to play a critical role in the rupture of intracranial, saccular aneurysms.
Objective:
The objective of this study was to investigate the gene expression pattern of saccular aneurysms with distinct morphologic patterns.
Methods:
Elastase-induced saccular aneurysms with high (>or= 2.4) and low (
Results:
Fourteen genes (4.8%) were differentially expressed in high-AR aneurysms compared with low-AR aneurysms. The expression of osteopontin, tissue inhibitor of matrix metalloproteinase, haptoglobin, cathepsin L, collagen VIII, fibronectin, galectin 3, secreted frizzled-related protein 2, CD14, decorin, and annexin I were up-regulated, whereas the expression of myosin light chain kinase, Fas antigen, and CD34 were down-regulated in high-AR aneurysms.
Conclusion:
In a rabbit model of saccular aneurysm, high AR was associated with differential expression of inflammatory/immunomodulatory genes, structural genes, genes related to proteolytic enzymes and extracellular matrix-related genes. These findings may focus efforts on targets aimed at avoiding spontaneous rupture of intracranial, saccular aneurysms.
