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Related Experiment Video

Updated: Jun 16, 2026

A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2
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Circulating bactericidal/permeability-increasing protein (BPI) is associated with serum lipids and endothelial

Eduardo Esteve1, Antoni Castro, Jose Maria Moreno

  • 1Section of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomédica de Girona, Girona, Spain.

Thrombosis and Haemostasis
|February 23, 2010
PubMed
Summary

Bactericidal/permeability-increasing protein (BPI) may serve as a biomarker for lipid metabolism and endothelial function. Higher BPI levels correlate with improved lipid profiles and vascular reactivity in men with normal glucose tolerance.

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Area of Science:

  • Biochemistry
  • Cardiovascular Research
  • Immunology

Background:

  • Bactericidal/permeability-increasing protein (BPI) is a neutrophil protein with anti-inflammatory effects.
  • BPI shares structural similarities with proteins involved in lipid metabolism.
  • The role of circulating BPI as a biomarker for endothelial function and lipid metabolism is not well-established.

Purpose of the Study:

  • To evaluate circulating BPI as a potential biomarker for endothelial function and lipid metabolism.
  • To investigate the association between BPI levels and serum lipid profiles.
  • To explore the relationship between BPI concentration and brachial vascular reactivity.

Main Methods:

  • Measurement of circulating BPI concentrations using ELISA in 202 Caucasian non-smoking men.
  • Assessment of serum lipids (total cholesterol, LDL-C, HDL-C).
  • Evaluation of brachial vascular reactivity via high-resolution external ultrasound in a subgroup of 91 subjects.

Main Results:

  • Plasma BPI concentrations showed positive correlations with total cholesterol, LDL cholesterol, and HDL cholesterol.
  • BPI levels were independent predictors of HDL-C, total cholesterol, and LDL-cholesterol variance.
  • BPI concentration positively correlated with endothelium-dependent vasodilatation and HDL-C in subjects with normal glucose tolerance.

Conclusions:

  • Circulating BPI may serve as a biomarker for lipid metabolism in individuals with normal glucose tolerance.
  • BPI could help identify subjects with preserved endothelial function.
  • Further research is warranted to elucidate the precise role of BPI in cardiovascular health.