Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

Introduction to Hemostasis

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...

Rh Blood Group

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.

Disorders of Hemostasis

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.

Venous Thrombosis IV: Nursing Management

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

IVF patient subgroups benefit from preimplantation genetic testing for aneuploidy: a prospective multicentre cohort study.

Reproductive biomedicine online·2026

Same author

Optimizing the protocol for modified natural cycle frozen embryo transfer (mNC-FET): a multicentre, single-blinded randomized controlled trial.

Human reproduction open·2026

Same author

Thyroid function in early pregnancy following frozen embryo transfer: analysis from a randomized controlled trial.

Journal of assisted reproduction and genetics·2025

Same author

Progesterone concentrations on blastocyst transfer day in modified natural cycle frozen embryo transfer cycles.

Reproductive biomedicine online·2024

Same author

The prevalence of late-follicular phase progesterone elevation and impact on the ongoing pregnancy rate after fresh and frozen blastocyst transfer. Sub-study of an RCT.

Human fertility (Cambridge, England)·2024

Same author

Correction: Hypertension genetic risk score is associated with burden of coronary heart disease among patients referred for coronary angiography.

PloS one·2023

Search research articles

Related Experiment Video

Updated: Jun 16, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

Haemostatic reference intervals in pregnancy.

Pal B Szecsi¹, Maja Jørgensen, Anna Klajnbard

¹Department of Clinical Biochemistry, Gentofte Hospital, University of Copenhagen, Denmark. palsze01@geh.regionh.dk

Thrombosis and Haemostasis

|February 23, 2010

Summary

This summary is machine-generated.

Establishing gestational age-specific reference intervals for coagulation tests is crucial for accurately diagnosing and treating haemostatic disorders in pregnant women. This study provides essential reference values for various haemostasis parameters throughout pregnancy and postpartum.

More Related Videos

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

Published on: February 27, 2026

Related Experiment Videos

Last Updated: Jun 16, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

Published on: February 27, 2026

Area of Science:

Obstetrics and Gynecology
Hematology
Clinical Chemistry

Background:

Standard haemostatic reference intervals are derived from non-pregnant individuals, potentially leading to misdiagnosis in pregnant women.
Accurate interpretation of coagulation tests is vital for managing haemostatic disorders during pregnancy, delivery, and postpartum.

Purpose of the Study:

To establish gestational age-specific reference intervals for key coagulation tests during normal pregnancy.
To compare haemostatic parameters in pregnant women with established non-pregnant reference ranges.

Main Methods:

Plasma samples were collected from 801 women with expected normal pregnancies at multiple gestational stages and postpartum.
Reference intervals were calculated for 391 uncomplicated pregnancies for activated partial thromboplastin time (aPTT), fibrinogen, fibrin D-dimer, antithrombin, free protein S, and protein C.
Additional tests, including prothrombin time (PT) and coagulation factors, were analyzed in a subgroup of 186 women.

Main Results:

Coagulation factors II, V, X, XI, XII, antithrombin, protein C, aPTT, and PT remained stable and within non-pregnant ranges.
Fibrinogen, D-dimer, and factors VII, VIII, and IX significantly increased during pregnancy.
Protein S activity decreased markedly, while free protein S showed a slight decrease and total protein S remained stable.

Conclusions:

Gestational age-specific reference values are essential for accurate interpretation of haemostasis tests during pregnancy, delivery, and puerperium.
Significant changes in specific coagulation parameters necessitate distinct reference ranges for pregnant populations.