Related Experiment Video
Updated: Jun 16, 2026
09:09
Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice
Published on: August 9, 2013
Renal disease in systemic sclerosis with normal serum creatinine
Reem H A Mohamed1, Hania S Zayed, Amr Amin
1Department of Rheumatology and Rehabilitation, Faculty of medicine, Cairo University, Cairo, Egypt. rmhamdy@yahoo.com
Clinical Rheumatology
|February 23, 2010
Summary
Systemic sclerosis patients often have reduced Glomerular Filtration Rate (GFR), indicating kidney impairment. Early screening using measured GFR is crucial, as formulas may underestimate subclinical renal involvement.
Area of Science:
- Nephrology
- Rheumatology
- Internal Medicine
Background:
- Prognosis in systemic sclerosis is significantly influenced by internal organ involvement.
- Renal impairment is a critical complication affecting patient outcomes.
Purpose of the Study:
- To evaluate renal impairment in systemic sclerosis patients.
- To compare measured Glomerular Filtration Rate (GFR) with calculated GFR using Cockcroft-Gault and MDRD formulas.
Main Methods:
- Recruited 31 systemic sclerosis patients and 31 healthy controls.
- Measured GFR using the TC99mDTPA Gates method.
- Calculated GFR using modified Cockcroft-Gault and MDRD equations.
Main Results:
- 54.9% of patients showed reduced GFR via the Gates method, with stages of chronic kidney disease identified.
- Formulas underestimated GFR reduction in 35.29% (Cockcroft-Gault) and 41.17% (MDRD) of affected patients.
- Renal involvement correlated positively with pulmonary vascular involvement (p=0.04).
Conclusions:
- Measured GFR is more precise than formulas for detecting subclinical renal involvement in systemic sclerosis.
- Routine screening for renal impairment is recommended for all systemic sclerosis patients, regardless of disease severity or duration.
Related Concept Videos
01:25Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance
In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance (Clcr), a...
01:28Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
01:24Chronic Kidney Disease II: Clinical Manifestations
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
01:28Chronic Kidney Disease III: Interprofessional Care
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
01:24Serum Studies: Renal Function Tests
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
01:17Factors Affecting Renal Clearance: Renal Impairment
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...