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Updated: Jun 16, 2026

International Expert Consensus and Recommendations for Neonatal Pneumothorax Ultrasound Diagnosis and Ultrasound-guided Thoracentesis Procedure
Published on: March 12, 2020
Safety of large-volume thoracentesis
Jafar Abunasser1, Robert Brown
1Department of Internal Medicine, Saint Vincent's Medical Center, Bridgeport, USA.
Large-volume thoracentesis, removing over 1 liter of pleural fluid, is safe and comparable in risk to small-volume procedures. This study found no increased risk of complications like hypotension or pneumothorax.
Area of Science:
- Pulmonology
- Thoracic Surgery
- Interventional Pulmonology
Background:
- Thoracentesis is a common procedure for pleural effusion management.
- Concerns exist regarding the safety of large-volume fluid removal (>1 liter) without intrapleural pressure monitoring.
Purpose of the Study:
- To evaluate the safety and associated risks of large-volume thoracentesis (>1 liter) compared to small-volume thoracentesis (<1 liter).
- To determine complication rates including hypotension, pneumothorax, and bleeding in large-volume thoracentesis.
Main Methods:
- Retrospective chart review of thoracenteses performed at a community-based teaching hospital.
- Analysis of 300 procedures (137 large-volume, 163 small-volume) between February 2004 and March 2006.
- Documentation of rates of hypotension, pneumothorax, bleeding, and re-expansion pulmonary edema.
Main Results:
- No statistically significant increase in the risk of pneumothorax, hypotension, or bleeding was observed with large-volume thoracentesis.
- One case of re-expansion pulmonary edema occurred following the removal of 2600 mL of fluid.
- Complication rates were comparable between large-volume and small-volume thoracentesis groups.
Conclusions:
- Large-volume thoracentesis is a safe procedure.
- The risks associated with removing >1 liter of pleural fluid are comparable to those of small-volume thoracentesis.
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