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Updated: Jun 16, 2026

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

Isolated patellofemoral osteoarthritis.

Hans-Peter W van Jonbergen¹, Rudolf W Poolman, Albert van Kampen

¹Department of Orthopedic Surgery, Deventer Hospital, Deventer. vanjonbergen@dz.nl

Acta Orthopaedica

|February 24, 2010

Summary

Optimal treatment for isolated patellofemoral osteoarthritis remains unclear. Total knee replacement with patellar resurfacing offers predictable, durable results, while other surgical options show limited improvement.

Area of Science:

Orthopedics
Rheumatology
Evidence-Based Medicine

Background:

Isolated patellofemoral osteoarthritis treatment is not well-defined.
A systematic review of nonoperative and operative treatments was conducted.

Purpose of the Study:

To systematically review the highest level of evidence for treating isolated patellofemoral osteoarthritis.
To develop an evidence-based discussion of treatment options.

Main Methods:

Systematic database search (Cochrane, PubMed, EMBASE) in March 2009.
Study quality assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.

Main Results:

Evidence quality for patellofemoral osteoarthritis treatments is generally low.

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Nonoperative treatments (physiotherapy, taping, injections) may offer short-term relief.

Total knee replacement with patellar resurfacing and patellofemoral arthroplasty show good, durable results in selected patients.

Conclusions:

High-quality comparative studies are needed to determine optimal treatment strategies.
Current evidence suggests limited benefits from joint-preserving surgery.
Total knee replacement and patellofemoral arthroplasty are viable options.